Wellmune® is a natural yeast beta 1,3/1,6 glucan derived from the cell wall of a highly purified, proprietary strain of baker’s yeast (Saccharomyces cerevisiae). This unique immune boosting ingredient triggers human immune defenses that have evolved over thousands of years to protect the body.
The scientific understanding of Wellmune’s mechanism of action in the body is well documented in published, peer-reviewed research. Mechanism of action studies as well as measurement of significant changes in immune responses are changing the way the scientific community thinks about innate immune function.
Once swallowed, immune cells in the gastrointestinal tract take up Wellmune and transport it to immune organs throughout the body. While in the immune organs, immune cells called macrophages digest Wellmune into smaller fragments and slowly release them over a number of days. The fragments bind to neutrophils, via complement receptor 3 (CR3), which are the most abundant immune cells in the body. In fact, neutrophils account for 40-60% of all immune cells.
Wellmune primes and strengthens the key immune function of neutrophils that now more quickly move throughout the body. Unlike other immune health ingredients, Wellmune boosts immune function without over stimulating the immune system.
Researchers discovered the mechanism through a series of experiments, including those with CR3-deficient-mice that confirmed the critical role this receptor plays in triggering an immune response. Other studies tracked fluorescently dyed Wellmune as immune cells transported it throughout the body or measured significant improvements in immune defense.