0

Clinical Research Conducted at University of Southampton

EAGAN, MN – June 20, 2014 – Wellmune WGP®, the natural immune-boosting ingredient for foods, beverages and supplements, supported the health of older adults during cold and flu season, according to a new clinical study conducted at the University of Southampton in the UK.

SouthamptonThe study consisted of 100 healthy adults aged 50-70 years consuming 250 mgs of Wellmune or a placebo for 90 days. Wellmune demonstrated a trend towards reducing the number of upper respiratory tract infections (URTI) and statistically significant changes and trends in cytokine levels that are part of the body’s response to viral encounters and inflammation.

“The reduction in URTI symptoms coupled with the modulation of key cytokines indicates the potential health benefits of Wellmune for older adults whose immune systems have become less robust with age,” said Donald Cox, Ph.D, senior vice president, Biothera Healthcare Research & Development. “We will use the results of this pilot study to design a larger, properly powered study to more fully evaluate the benefits of Wellmune in older adults.”

Richard Fuller, M.D., who led the study within the Department of Primary Care and Population Science, said: “Respiratory infections are a major source of health burden and a leading cause for antibiotic use. The concept of using Wellmune as a nutritional supplement to support immune defences was very popular with study participants. The results of this pilot are encouraging and further studies certainly seem justified.”

Wellmune is a proprietary beta 1/3, 1/6 glucan from baker’s yeast that naturally boosts innate immune cells that help keep the body healthy. Ten human clinical studies consistently demonstrate the ability of Wellmune to reduce URTI symptoms, enhance vigor and mental clarity, and reduce fatigue.

“Older adults are one of the world’s largest population segments, and there is a growing need for products that deliver natural immune support,” said Richard G. Mueller, Biothera chief executive officer. “Our impressive body of research demonstrates the safety and efficacy of Wellmune, making it the ideal ingredient for aging consumers.”

Study Design & Results
The double-blinded study included 100 older adults (ages 50-70) who are at a stage of life where age-related immune decline may underlie susceptibility to health challenges. Study participants were randomized into two groups, one receiving a placebo and the other 250 mgs of Wellmune for 90 days during the peak cold and flu season.

An URTI episode was classified as two or more symptoms for two consecutive days, confirmed by medical assessment. Blood and saliva samples were collected at days 0, 45 and 90 to measure serum and Lipopolysaccharide (LPS)-stimulated whole-blood cytokines and chemokines. LPS is a component of the cell wall of gram-negative bacteria that is used to mimic the presence of infection.

The data from the Wellmune subjects trended towards prevention of URTI. Statistically significant changes and trends were observed in cytokine levels, including IL-12p70 and IL-10, interferon gamma and MIG (Monokine Induced by Gamma interferon/ CXCL9). These cytokines are chemical messengers that help the body response to challenges.

The research was conducted by the Faculty of Medicine at the University of Southampton, Southampton, UK, and presented at the Southampton Translational Clinical Research Conference. The study is entitled, “Yeast-Derived 1,3/1,6 Glucopolysaccharide to Prevent Upper Respiratory Tract Infection and Modulate Circulating Cytokines and Chemokines in Older Adults.” Publication of the data is pending.

About Wellmune WGP®
Wellmune WGP is 100% natural baker’s yeast beta 1,3/1,6 glucan that has been clinically proven to strengthen key immune cells that help keep the body healthy. This natural food, beverage and supplement ingredient has regulatory approval in major markets around the world, including GRAS status in the U.S. and novel food approval in Europe and China. Products containing Wellmune are available in more than 60 countries. Wellmune is patented, Kosher, Halal, non-allergenic and GMO-free. A recipient of numerous food industry awards for scientific excellence, Wellmune is a product of Biothera, a U.S. biotechnology company dedicated to improving immune health.

Contact:
David Walsh
SVP Marketing & Communications
Biothera, the Immune Health Company
651-256-4606
dwalsh@biothera.com

 

0

Results of Study in 310 Children Published in Pediatrics

EAGAN, MN – June 19, 2014 – A study demonstrating that a follow-up formula containing a combination of DHA, a prebiotic blend of PDX and GOS, and yeast β-glucan supported the immune systems of healthy three- and four-year-olds was published in the June issue of Pediatrics, the official journal of the American Academy of Pediatrics.

Pediatrics cover 6-14Children who consumed the follow-up formula (FUF) designed for this study by Mead Johnson Nutrition had fewer episodes and shorter duration of acute respiratory infections (P = .007) than children consuming an unfortified cow’s milk-based beverage. They also required fewer antibiotic treatments (P = .01) and missed fewer days of day care due to illness, the study found. In addition, the FUF group had both higher interleukin-10 and white blood cell (WBC) counts at the end of the study, suggesting an anti-inflammatory mechanism and/or an increase of effector immune cells. (WBC counts remained in the normal range.)

In a double-blind, randomized, controlled, prospective trial, 3-4 year old children were fed 3 servings per day of either a FUF containing 25 mg DHA, 1.2 g PDX/GOS, and 8.7 mg yeast β-glucan (Wellmune WGP®) per serving or an unfortified, cow’s milk-based beverage (control) for 28 weeks. Fecal and blood samples were collected to assess immune markers and iron/zinc status. Incidence of acute respiratory infections, diarrheal disease, and antibiotic treatment were obtained from medical records.

“As the study’s authors noted, children are vulnerable to diet inadequacies, which may affect immune function,” said Donald Cox, Ph.D., senior vice president, Healthcare Research & Development at Biothera, the manufacturer of Wellmune WGP. “This research demonstrates the importance of supporting the developing immune systems of young children.”

The research paper is entitled, “Follow-up Formula Consumption in 3- to 4-Year-Olds and Respiratory Infections: An RCT.” Pediatrics. 2014 May 19. pii: peds.2013-3598.

Wellmune WGP is an ingredient in Mead Johnson Enfagrow® and Enfakid® Premium children nutritional products in numerous countries in Asia and Latin America. The FUF used in this study is not a marketed product at this time.

About Wellmune WGP®
Wellmune WGP is 100% natural baker’s yeast beta 1,3/1,6 glucan that has been clinically proven to strengthen key immune cells that help keep the body healthy. This natural food, beverage and supplement ingredient has regulatory approval in major markets around the world, including GRAS status in the U.S. and novel food approval in Europe and China. Products containing Wellmune are available in more than 60 countries. Wellmune is patented, Kosher, Halal, non-allergenic and GMO-free. A recipient of numerous food industry awards for scientific excellence, Wellmune is a product of Biothera, a U.S. biotechnology company dedicated to improving immune health.

Contact:
David Walsh
SVP Marketing & Communications
Biothera, the Immune Health Company
651-256-4606
dwalsh@biothera.com

0

Largest Juice Company in Thailand Launches Tipco Super Kid Juices Featuring Disney Characters

EAGAN, MN – June 10, 2014 – Tipco F&B Co., Ltd., the largest juice company in Thailand, has launched Super Kid™ mixed berry juice containing Wellmune WGP®, vitamins and antioxidants to strengthen the immune systems of children ages three to eight.

Tipco SuperKid juice with WellmuneThe 100% mixed berry juice is the first of several new flavors in the Super Kid product line that will contain Wellmune WGP, which is clinically proven to boost key immune cells that help keep the body healthy. The RTD juice comes in a single-serving Tetra Pak with a straw and contains 43 milligrams of Wellmune. The Tipco Super Kid line features animated characters licensed from the Walt Disney Company.

“We selected Wellmune for Tipco Super Kid because of the strong clinical research demonstrating its ability to strengthen the immune system and support overall health and wellness,” said Orathai Buranapanichpun, Tipco Research and Development Project Manager.

“Nothing is more important than the health and well being of children,” said Richard G. Mueller, chief executive officer of Biothera. “We are pleased to partner with Tipco F&B Company to make the immune health benefits of Wellmune available to children in Thailand.”

Tipco Super Kid is available at supermarkets and convenience and grocery stores throughout Thailand.

About Tipco F&B Co., Ltd.
Established in 1976, Tipco F&B Co., Ltd. is a manufacturer, exporter and distributor of various canned/frozen/pouched/juice fruits, vegetable and ready to drink green tea products under the brand Tipco.  Its production line produces 100% pasteurized fruit and vegetable juices, including mixed veggie juice, beetroot juice, aloe vera and white grape juice, and guava juice. For more information, visit www.tipco.net

About Wellmune WGP®
Wellmune WGP is 100% natural baker’s yeast beta 1,3/1,6 glucan that has been clinically proven to strengthen key immune cells that help keep the body healthy. This natural food, beverage and supplement ingredient has regulatory approval in major markets around the world, including GRAS status in the U.S. and novel food approval in Europe and China. Products containing Wellmune are available in more than 60 countries. Wellmune is patented, Kosher, Halal, non-allergenic and GMO-free. A recipient of numerous food industry awards for scientific excellence, Wellmune is a product of Biothera, a U.S. biotechnology company dedicated to improving immune health.

Contact:
David Walsh
SVP Marketing & Communications
Biothera, the Immune Health Company
651-256-4606
dwalsh@biothera.com

 

0

EAGAN, MN – June 3, 2014 – Scimera BioScience has introduced SciMune™, a physician-formulated dietary supplement that supports healthy immune function and energy levels through a unique combination of Wellmune WGP®, antioxidants, herbals, extracts and vitamins and minerals.

Wellmune WGP is a natural and proprietary beta 1,3/1,6 glucan that is a clinically proven to boost key immune cells that help keep the body healthy. Nine clinical studies consistently demonstrate the ability of Wellmune to improve overall health, even during periods of high physical or lifestyle stress.

Scimera BioScience SciMune“Scimera BioScience is a bioceutical company based on real science and evidence-based ingredients,” Fred Chaleff, M.D., founder and chief executive officer. “Wellmune was a perfect fit for us, with its human clinical studies, peer-reviewed research and natural ingredients.”

“Scimera BioScience and Biothera share a commitment to developing products backed by strong, credible science,” said Richard G. Mueller, Biothera chief executive officer. “We are pleased that Wellmune WGP has been selected as the lead ingredient in SciMune.”

SciMune contains a clinically proven efficacious serving of 300 mgs of Wellmune in vegetarian capsules. SciMune is available in convenient four-day blister packs in grocery and specialty stores in nearly all U.S. states, as well as online. SciMune is also currently sold in Puerto Rico and the Caribbean and will expand to the European market. The suggest retail price is $14.95.

“SciMune is designed to provide immune support for travelers, office workers, students and others in close contact with people,” said Dr. Chaleff. “In addition to these close-quarter situations, SciMune also delivers year-round immune support for overall health and wellness.”

About Scimera BioScience
Scimera BioScience® develops cutting-edge bioceuticals that address cardiovascular, immune system, bone and joint, gastrointestinal, respiratory, prostate and a wide array of health issues. The Scimera BioScience Team is comprised of physicians, pharmacists, chemists, consumer advocates and a management team with extensive clinical exposure and expertise, all with the goal of producing science-based health support.

The company utilizes the best clinical studies, advanced ingredient research, and evidence-based data, and strives to promote better understanding of the disease process, and the importance of proactive intervention. All products are made in the USA in an FDA-inspected facility that meets the stringent standards of current Good Manufacturing Practices (GMP).

Scimera BioScience is constantly researching and developing the newest and latest products that will meet consumer health needs and allow consumers to focus on better health through advanced Bioscience. For more information, visit www.scimera.com.

About Wellmune WGP®
Wellmune WGP is 100% natural baker’s yeast beta 1,3/1,6 glucan that has been clinically proven to strengthen key immune cells that help keep the body healthy. This natural food, beverage and supplement ingredient has regulatory approval in major markets around the world, including GRAS status in the U.S. and novel food approval in Europe and China.  Products containing Wellmune are available in more than 60 countries. Wellmune is patented, Kosher, Halal, non-allergenic and GMO-free. A recipient of numerous food industry awards for scientific excellence, Wellmune is a product of Biothera, a U.S. biotechnology company dedicated to improving immune health. Visit us at www.wellmune.com.

Contacts:
David Walsh
SVP Marketing & Communications
Biothera, the Immune Health Company
651-256-4606
dwalsh@biothera.com

Jean De Boyrie
Director Of Marketing
Scimera BioScience
T: (305) 662-4065
F: (305) 662-5519
www.scimera.com

 

 

0

Immune Modulation Benefits of Yeast Beta Glucan, Omega 3 and Prebiotic Blend Highlighted in a Nutritional Study

EAGAN, MN – May 29, 2014 – Consumption of a milk-based children’s formula (supplied by Mead Johnson Nutrition) helped healthy children ages 1-4 years experience fewer episodes of allergy symptoms compared with healthy children consuming unfortified cow’s milk. The research results were recently presented at Experimental Biology meeting in San Diego.

Consumption of nutrients such as docosahexaenoic acid (DHA), prebiotics, and beta-glucan has been associated with a decrease in the occurrence of allergic manifestations (AM). In a double-blind, randomized, controlled trial, healthy 1 to 4 year old children from two daycare centers in Brazil were fed three servings/day of a cow’s milk-based follow-up formula with DHA, prebiotics, polydextrose and galactooligosaccharides, and beta-glucan or an unfortified cow’s milk-based beverage for up to 28 weeks. Occurrence of AM was assessed by study pediatricians and analyzed by the Cochran-Mantel-Haenszel test and the counting process of Andersen-Gill.

The study demonstrated that children consuming the fortified cow’s milk formula had fewer episodes of AM, which included allergic rhinitis, conjunctivitis, wheezing, allergic cough, eczema and urticaria, and a lower hazard ratio for having AM (HR, 0.64; 95% CI 0.47-0.89; p=0.007).

“This research further demonstrates the importance of immune support and modulation for young children whose immune systems are still developing,” said Richard G. Mueller, Biothera chief executive officer. “The study results are consistent with Biothera’s own research demonstrating that Wellmune WGP reduced allergy symptoms and improved the quality of life in adults.”

Wellmune WGP is an ingredient in Mead Johnson Enfagrow® and Enfakid® Premium children nutritional products in numerous countries in Asia and Latin America.

The study citation:
Deolinda Scalabrin2, Tereza Ribeiro1, Angela Peixoto de Matto1, Weihong Zhuang2, Suzanne Stolz2, Mariana Pontes1, Indhira Almeida1, Carolina Godoy1, Sara Gatto1, Vivian Leal1, G Cabral1 and Hugo Ribeiro1. Formula with docosahexaenoic acid, prebiotics, and beta-glucan supports respiratory and skin health in children. April 2014 The FASEB Journal vol. 28 no. 1 Supplement 382.6. 1Federal University of Bahia Salvador, Bahia Brazil 2Mead Johnson Pediatric Nutrition Institute Evansville IN United States.

About Wellmune WGP®
Wellmune WGP is 100% natural baker’s yeast beta 1,3/1,6 glucan that has been clinically proven to strengthen key immune cells that help keep the body healthy. This natural food, beverage and supplement ingredient has regulatory approval in major markets around the world, including GRAS status in the U.S. and novel food approval in Europe and China. Products containing Wellmune are available in more than 60 countries. Wellmune is patented, Kosher, Halal, non-allergenic and GMO-free. A recipient of numerous food industry awards for scientific excellence, Wellmune is a product of Biothera, a U.S. biotechnology company dedicated to improving immune health.

Contact:
David Walsh
SVP Marketing & Communications
Biothera, the Immune Health Company
651-256-4606
dwalsh@biothera.com

0

EAGAN, MN – April 24, 2014 – Biothera, manufacturer of Wellmune WGP®, the natural immune booster for foods, beverages and supplements, announced today the selection of Naturalendo Tech Co., Ltd. (Naturalendo) to be its exclusive distribution partner in South Korea following Naturalendo’s successful effort to secure regulatory approval for Wellmune.

Naturalendo logoWellmune received an immune health claim and earned a Certificate of Functional Ingredient for Health/Functional Food in compliance with Article 14 and 15 of the Health Functional Food Act of the Republic of Korea from the Korean Ministry of Food and Drug Safety (MFDS). Wellmune met all standards for safety and efficacy during the rigorous, nearly 2-year approval process.

Naturalendo has deep expertise in supporting the commercialization of functional foods in Asia and the Americas and has been recognized with numerous awards from various ministries within the Korean government including the MFDS.

Wellmune is a beta 1,3/1,6 glucan derived from a proprietary strain of baker’s yeast. Nine human clinical studies consistently demonstrate the ability of Wellmune to safely boost key immune cells that keep the body healthy.

“The clinical evidence behind Wellmune will enable us to make a compelling case for including this outstanding ingredient in a wide range of food, beverage and supplement products,” said R&D Center Chief KT Yi, Naturalendo. “We are excited to share the many benefits of including Wellmune in the diet throughout the life cycle, whether supporting the developing immune system in young children to sports nutrition, helping people manage physical and psychological stressors, and supporting the aging of the immune system in our older population.”

Other immune enhancers cannot compare to the strong science backing Wellmune, Yi added, noting that Korea has one of the toughest regulatory environments in the world for functional ingredients.

“Achieving regulatory approval in Korea was a milestone for the Wellmune brand and a testament to the safety and efficacy of our proprietary ingredient,” said Richard G. Mueller, chief executive officer, Biothera. “With Naturalendo’s expertise and keen insights about the marketplace, we are excited about the potential for bringing a wide range of food, beverage and supplement products with Wellmune to consumers in Korea.”

About Naturalendo Tech Co., Ltd.
Founded in 2001, Naturalendo Tech Co., Ltd. is a biotech company certified by the Korean government.  It has its roots in research and development of cutting-edge novel ingredient technologies to support human growth and development. Naturalendo is listed on the Korean version of NASDAQ with a market cap of approximately $600 million US.

About Wellmune WGP®
Wellmune WGP is a proprietary baker’s yeast beta 1,3/1,6 glucan that is clinically proven to prime key immune cells that keep the body healthy. This natural food, beverage and supplement ingredient has regulatory approval around the world, including GRAS status in the U.S. and novel foods approval in Europe and China. Wellmune is available in more than 60 countries around the world. It is also patented, Kosher, Halal, non-allergenic and GMO-free. Wellmune is the 2013 recipient of the NBT Award for Outstanding Application in Health Management. It has also received an IFT Innovation Award, a SupplySide West Scientific Excellence Award and a Frost & Sullivan Excellence in Research Award. Wellmune WGP is a product of Biothera, a U.S. biotechnology company dedicated to improving immune health.

Contact:
David Walsh
SVP Marketing & Communications
Biothera, the Immune Health Company
651-256-4606
dwalsh@biothera.com

 

0

EAGAN, MN – March 3, 2014 – Wellmune WGP®, the natural immune booster from Biothera, is a key ingredient in a reinvented immune health supplement from Twinlab, a leading North American supplement manufacturer and marketer. Twinlab Immunity Booster™ is launching during Natural Products Expo West March 7-9 in Anaheim and will be available nationally through health and natural foods stores and online through the Twinlab website.

Twinlab Immunity Booster Box

Wellmune is a beta 1,3/1,6 glucan derived from a proprietary strain of baker’s yeast. Nine human clinical studies consistently demonstrate the ability of Wellmune to safely boost key immune cells that help keep the body healthy. Research shows that high intensity exercise may temporarily weaken the immune system and over time may derail training programs and performance gains.

Wellmune is clinically tested to boost the immune system to help keep the body healthy. Published, peer-reviewed studies demonstrate that Wellmune mobilizes billions of innate immune cells that are part of the body’s natural defenses.

“We set out to develop a more robust, clinically relevant immune health supplement to meet growing consumer demand for immune support,” said Gene Bruno, MS, MHS, Director of Category Management, Twinlab Corp. “Wellmune is the ‘hero ingredient,’ given its deep portfolio of peer-reviewed, published human clinical research demonstrating efficacy for everyday immune support and upper respiratory health.”

“Twinlab Immunity Booster containing Wellmune is an exciting new option for consumers seeking an effective way to help stay well,” said Richard G. Mueller, CEO, Biothera. “Launch during the Spring season is timely. It’s a good reminder that immune support is an everyday need year round, and not just seasonal.”

Twinlab Immunity Booster is available in a 90-capsule bottle. Three capsules daily will deliver the clinically tested serving of 250 mg of Wellmune. The suggested retail price is $29.99.

Wellmune is currently in food, beverages and supplements in more than 60 countries around the world.

About Twinlab®
Twinlab Corporation is a leading manufacturer and marketer of high quality, science-based, nutritional supplements and sports nutrition products. Since 1968, the Twinlab brand has manufactured and marketed nutritional supplements in both the vitamin and sports nutrition categories. In addition to its namesake brand, Twinlab Corporation also manufactures and sells other well-known category leaders including the Metabolife® line of diet and energy products; Fuel® line of sports supplement products; Alvita® teas, established in 1922 as a single-herb tea line; Trigosamine® joint support products as well other health and wellness brands. Twinlab’s manufacturing facility in American Fork, Utah is an NSF GMP registered facility. Twinlab also runs a scientific and regulatory facility in Grand Rapids, Michigan; and has its corporate headquarters in New York, NY. Visit www.twinlab.com for more information.

About Wellmune WGP®
Wellmune WGP is a proprietary baker’s yeast beta 1,3/1,6 glucan that is clinically shown to prime key immune cells that keep the body healthy. This natural food, beverage and supplement ingredient has regulatory approval around the world, including GRAS status in the U.S. and novel foods approval in Europe and China. It is also patented, Kosher, Halal, non-allergenic and GMO-free. Wellmune is the 2013 recipient of the NBT Award for Outstanding Application in Health Management. It has also received an IFT Innovation Award, a SupplySide West Scientific Excellence Award and a Frost & Sullivan Excellence in Research Award. Wellmune WGP is a product of Biothera, a U.S. biotechnology company dedicated to improving immune health.

Biothera Media Contact:
David Walsh
VP Communications
Biothera, the Immune Health Company
dwalsh@biothera.com
651-256-4606

Twinlab Media Contact:
Susan Fecko
Percepture
sfecko@percepture.com
303-449-8381

0

SunRype FruitActiv™ Immuniboost™ bars with Wellmune.

SunRype FruitActiv™ Immuniboost™ bars with Wellmune WGP®.



EAGAN, MN – February 26, 2014 – Wellmune WGP®, the natural immune booster from Biothera, is now in a line of fruit and whole grain bars from a leading fruit snack manufacturer. The FruitActiv™ Immuniboost™ bars from British Columbia-based Sun-Rype Products Ltd., are available at grocery stores, supermarkets, mass merchandisers and club channel stores throughout Canada.

Wellmune is a natural beta 1,3/1,6 glucan derived from a proprietary strain of baker’s yeast. Wellmune is clinically proven to safely boost the immune system to keep the body healthy. Eight published, peer-reviewed studies demonstrate that Wellmune mobilizes billions of innate immune cells that are part of the body’s natural defenses, without over stimulating the immune system.

“Sun-Rype’s R&D department is highly skilled at developing formulations that maximize taste while incorporating functional ingredients with meaningful benefits, such as clinically proven Wellmune WGP for immune support,” said Barb Broder, Group Marketing Manager-Food, Sun-Rype. “With the addition of our FruitActiv Immuniboost line containing Wellmune, boomers and other health-conscious consumers now have an easy way to give their immune system a boost with the goodness of a fruit and whole grain snack.”

“Bars are an ideal delivery vehicle for Wellmune’s everyday, year-round immune support,” said Richard G. Mueller, Biothera Chief Executive Officer. “The FruitActiv Immuniboost bars align with key consumer trends – on the go convenience, wholesome ingredients and functional benefits.”

The bars are available in a choice of Mango Twist or Orange Squeeze flavors. Each bar contains 100 mg of Wellmune. The suggested retail price per bar is $1.49-$1.99.

Currently, there are more than 100 products with Wellmune in more than 60 countries around the world.

About SunRype
Sun-Rype Products Ltd., based in Kelowna, BC, is a manufacturer and marketer of fruit-based juices and snacks. For more information visit www.sunrype.com.

About Wellmune WGP®
Wellmune WGP is a proprietary baker’s yeast beta 1,3/1,6 glucan that is clinically proven to prime key immune cells that keep the body healthy. This natural food, beverage and supplement ingredient has regulatory approval around the world, including GRAS status in the U.S. and novel foods approval in Europe and China. Wellmune is available in products in more than 60 countries around the world. It is also patented, Kosher, Halal, non-allergenic and GMO-free. Wellmune is the 2013 recipient of the NBT Award for Outstanding Application in Health Management. It has also received an IFT Innovation Award, a SupplySide West Scientific Excellence Award and a Frost & Sullivan Excellence in Research Award. Wellmune WGP is a product of Biothera, a U.S. biotechnology company dedicated to improving immune health.

Contact:
David Walsh
VP Communications
Biothera, the Immune Health Company
651-256-4606
dwalsh@biothera.com

0

Glycobiology[1]Research Published in Glycobiology

EAGAN, MN – February 13, 2014 – Wellmune WPG®, the immune health ingredient for foods, beverages and supplements from Biothera, utilizes distinct receptors and signaling pathways in certain white blood cells to induce cytotoxic function.The research was published in the latest issue of the peer-reviewed journal Glycobiology.

This new research describes how structurally different forms of yeast beta glucans utilize different receptors and associated signaling pathways to activate innate immune functions.Wellmune WGP is yeast-derived beta glucan that boosts innate immune cells that help keep the body healthy.

“This research further elucidates the mechanisms through which Wellmune WGP primes immune responses in key immune cells to enhances the body’s defenses,” said Don Cox, Ph.D., senior vice president of Biothera’s Healthcare Group’s R&D. “It also demonstrates that beta-glucan structure is a critical attribute in eliciting biological effects.”

In the study, different forms of Biothera beta glucan were used to activate human peripheral blood mononuclear cells and oxidative burst, one of the cytotoxic mechanisms used by innate immune cells. Both particulate and soluble forms of Biothera beta glucans bound to either complement receptor 3 (CR-3) or receptor Dectin-1 to initiate an immune response. These physically different forms of beta glucan induced this functional response through both overlapping and distinct signaling pathways.

The paper is entitled, “Differential regulation of oxidative burst by distinct β-glucan-binding receptors and signaling pathways in human peripheral blood mononuclear cells.”

The authors include Nandita Bose1, Lindsay R. Wurst1, Anissa SH. Chan1, Christine M. Dudney1, Megan L. LeRoux1, Michael E. Danielson1, Paul M. Will1, Sonja E. Nodland1, Myra L. Patchen1, Jurandir J. Dalle Lucca2, Frank J. Lebeda3, and John P. Vasilakos1.

1 Biothera, Eagan, MN 55121 USA
2 US Army Institute of Surgical Research, Ft. Sam Houston, 78234 USA TX
3 US Army Medical Research and Materiel Command, Ft. Detrick, MD 21701 USA

About Wellmune WGP®
Wellmune WGP is a proprietary baker’s yeast beta 1,3/1,6 glucan that is clinically proven to prime key immune cells that keep the body healthy. This natural food, beverage and supplement ingredient has regulatory approval around the world, including GRAS status in the U.S. and novel foods approval in Europe and China. Wellmune is available in more than 100 products in more than 50 countries around the world. It is also patented, Kosher, Halal, non-allergenic and GMO-free. Wellmune is the 2013 recipient of the NBT Award for Outstanding Application in Health Management. It has also received an IFT Innovation Award, a SupplySide West Scientific Excellence Award and a Frost & Sullivan Excellence in Research Award. Wellmune WGP is a product of Biothera, a U.S. biotechnology company dedicated to improving immune health.

Contact:
David Walsh
VP, Communications
Biothera, the Immune Health Company
651-256-4606
dwalsh@biothera.com

###

0

UntitledEAGAN, MN –Jan. 13, 2014 – U!be Group Inc., a leading product innovator in the health and wellness category in Taiwan, has selected Wellmune WGP®, the natural immune health ingredient from Biothera, for a new children’s lozenge, U!be Strong®. This is the second U!be Super Kids series product focused on immune and oral health for children and the first lozenge with Wellmune.

Wellmune is clinically proven to safely boost the immune system to keep the body healthy. Eight published, peer-reviewed studies demonstrate that Wellmune mobilizes billions of innate immune cells that are part of the body’s natural defenses, without over stimulating the immune system.

“U!be Strong® children’s lozenge was created to help parents maintain their children’s immune health in today’s harsh environment and hectic lifestyle,” said John Perng, Ph.D., U!be Group Inc.’s vice president of R&D and Business Development. “Upper respiratory tract infection (URTI) and allergy symptoms due to weakened immunity are all too common in modern-day, school-age children. We know from years of experience that Wellmune, with its U.S. FDA-notified GRAS status and solid body of clinical research, is the top immune-enhancing ingredient available. What we are doing now is to expand its benefit into the children’s nutritional products arena.”

“We are excited that U!be Group Inc. has chosen to incorporate Wellmune into its children nutritional product for Chinese markets throughout the world,” said Richard G. Mueller, Biothera chief executive officer.

Mueller added, “As consumers look for more ways to support their health and vitality, the broader availability of clinically proven Wellmune in brands they trust, offers peace of mind and worry-free convenience that contributes to healthy habits for a lifetime.”

About U!be Group Inc.
U!be Group Inc. is a pioneer in creating innovative nutraceutical products featuring clinically proven nutraceutical ingredients and novel delivery systems. The company’s goal is to provide natural solutions to health problems with its U!be brand of products that is efficacious yet affordable to the general public.

About Wellmune WGP®
Wellmune WGP is a proprietary baker’s yeast beta 1,3/1,6 glucan that is clinically proven to prime key immune cells that keep the body healthy. This natural food, beverage and supplement ingredient has regulatory approval around the world, including GRAS status in the U.S. and novel foods approval in Europe and China. Wellmune is available in more than 100 products in more than 60 countries around the world. It is also patented, Kosher, Halal, non-allergenic and GMO-free. Wellmune is the 2013 recipient of the NBT Award for Outstanding Application in Health Management. It has also received an IFT Innovation Award, a SupplySide West Scientific Excellence Award and a Frost & Sullivan Excellence in Research Award. Wellmune WGP is a product of Biothera, a U.S. biotechnology company dedicated to improving immune health.

Contact:
David Walsh
VP Communications
Biothera, the Immune Health Company
651-256-4606 (direct)
dwalsh@biothera.com