Wellmune

EAGAN, MN – Jan. 21, 2013 – Wellmune WGP^®, the natural immune health ingredient from Biothera, is now available in MediChá^®, a functional beverage in Taiwan made by U!be Group Inc., a leading innovator in the health and wellness category. MediChá^® is a unique tea concentrate shown to address the health concerns of people with metabolic syndrome.

Wellmune WGP is clinically proven to safely prime the immune system to keep the body healthy. Numerous peer-reviewed clinical studies demonstrate that Wellmune WGP mobilizes billions of innate immune cells that are part of the body’s natural defenses without artificially stimulating the immune system.

“We are excited that U!Be Group is expanding its offering and bringing Wellmune to the Chinese community through the tradition of drinking tea. MediChá with Wellmune is a perfect match of ancient wisdom of the East with a nutritional breakthrough from the West,” said Richard Mueller, chief executive officer, Biothera.

“MediChá synergistically combines the immune-strengthening mechanism of Wellmune and scientifically validated ingredients to help optimize glycemic response into a unique preparation of Pu-erh Tea concentrate from hundred-year-old tea trees,” added John Perng, Ph.D., U!be Group Inc.’s vice president of R&D and business development. “This triple combination of health benefits helps to enhance the immune system, promotes healthy metabolism and supports overall health.”

Mueller added, “MediChá with Wellmune is a great example of how beverage companies can create added value for their brand. Immune support is one of the most sought-after functional health benefits.”

About U!be Group Inc.

U!be Group Inc. is a pioneer in creating innovative nutraceutical products featuring clinically-proven nutraceutical ingredients and novel delivering systems. The company’s goal is to provide natural solutions to health problems with its U!be brand of products that is efficacious yet affordable to the general public. For more information visit www.ubelife.com.

About Wellmune WGP^®

Wellmune WGP is a proprietary baker’s yeast beta 1,3/1,6 glucan that is clinically proven to prime key immune cells that keep the body healthy. This natural food, beverage and supplement ingredient has regulatory approval around the world, including GRAS status in the U.S. and novel foods approval in Europe and China. Wellmune is available in more than 100 products in more than 50 countries around the world. It is also patented, Kosher, Halal, non-allergenic and GMO-free. In addition to receiving an IFT Innovation Award, Wellmune has received a SupplySide West Scientific Excellence Award and a Frost & Sullivan Excellence in Research Award. Wellmune WGP is a product of Biothera, a U.S. biotechnology company dedicated to improving immune health.

Contact:
David Walsh
VP Communications
Biothera, the Immune Health Company
651-256-4606 (direct)
dwalsh@biothera.com

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EAGAN, MN – January 14, 2013 – Wellmune WGP^®, the clinically proven natural immune health ingredient from Biothera, is now available in a drinkable yogurt product from Grupo Gloria, the largest commercial dairy company in Peru. Initial distribution is planned to retail locations across the country including supermarkets and convenience stores.

Gloria’s Pro Defensis marries the clinically proven systemic immune health benefits of Wellmune WGP with the gut health benefits of probiotics. It is the first-ever yogurt to combine these clinically proven benefits.

“Yogurt is an everyday, mainstream food product making it an ideal delivery system for the daily immune support that Wellmune WGP provides,” said Richard Mueller, CEO, Biothera. “We’re gratified that working closely with Gloria and our distributor Quimtia, yogurt now joins the wide range of applications for the proven immune health benefits of Wellmune WGP.”

Pro Defensis is available in vanilla and strawberry flavors. Each bottle delivers 100 mg of Wellmune. The recommended daily serving is 2.5 mg/kilo of body weight.

About Wellmune WGP^®

Wellmune WGP is a proprietary baker’s yeast beta 1,3/1,6 glucan that is clinically proven to boost key immune cells that keep the body healthy. This natural food, beverage and supplement ingredient has regulatory approval around the world, including GRAS status in the U.S. and novel foods approval in Europe and China. Wellmune is available in more than 100 products in more than 50 countries around the world. It is also patented, Kosher, Halal, non-allergenic and GMO-free. In addition to receiving an IFT Innovation Award, Wellmune has received a SupplySide West Scientific Excellence Award and a Frost & Sullivan Excellence in Research Award. Wellmune WGP is a product of Biothera, a U.S. biotechnology company dedicated to improving immune health.

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Contact:
David Walsh
VP Communications
Biothera, the Immune Health Company
651-256-4606 (direct)
651-675-0300 (main)
dwalsh@biothera.com

Food Science & Nutrition

EAGAN, MN, January 2, 2013—Wellmune WGP, a natural immune health ingredient for foods, beverages and supplements, helped modulate immune responses to improve overall health and quality of life, according to clinical results published online in the peer-reviewed journal Food Science & Nutrition.

Wellmune WGP modulated immune responses, as measured by a significantly significant reduction in allergy symptoms in people with ragweed allergies, according to researchers. An estimated 40 to 50 million Americans are affected by allergies, with ragweed a leading cause of seasonal allergy symptoms including nasal congestion, sneezing, itchy eyes and difficulty breathing. Allergy symptoms are caused by an immune system overreaction to ragweed pollen.

The placebo-controlled, double-blinded study of 48 healthy people who were subjected to high pollen counts demonstrated statistically significant (p<0.05):

• Reductions in overall symptoms and severity

• Reductions in key nasal and eye-related allergy symptoms

• Improvement on the Quality of Life Index, a scientifically validated tool for measuring how participants rate their overall sense of wellness.

Wellmune, a proprietary baker’s yeast beta glucan, activates innate immune cells that are part of the body’s natural defenses without over-stimulating the immune system. In this study, Wellmune was found to modulate the immune system when less of an immune response was needed.

The results of this study are consistent with numerous previous peer-reviewed, published studies demonstrating that Wellmune can safely boost the immune system to keep the body healthy.

“A daily regimen including all-natural Wellmune WGP is well-documented to safely support immune health, a key contributor to overall health and well-being,” said Richard G. Mueller, chief executive officer, Biothera. “This study shows that Wellmune can effectively modulate immune responses to help the immune system to achieve balance that is important to staying healthy.”

Study Design

The randomized, placebo-controlled, double-blind study included self-described “moderate” ragweed allergy sufferers. Forty-eight healthy subjects were equally divided (31 female, 17 male; 39± 13 years of age) into two groups. One group consumed a placebo while the other a 250 mg serving of Wellmune WGP daily for four weeks during September/October 2011 in an area of southeast Ohio with high pollen counts. Participants completed allergy surveys including the validated Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) to assess differences in allergy symptoms.

The research was funded by Biothera, Inc.

About Wellmune WGP^®

Wellmune WGP is a natural yeast beta 1,3/1,6 glucan that is clinically proven to boost key immune cells that keep the body healthy. This unique food, beverage and supplement ingredient has regulatory approval around the world, including GRAS status in the U.S. and novel foods approval in Europe and China.  It is also patented, Kosher, Halal, non-allergenic and GMO-free. In addition to receiving an IFT Innovation Award, Wellmune has received a SupplySide West Scientific Excellence Award and a Frost & Sullivan Excellence in Research Award. Wellmune WGP is a product of Biothera, a U.S. biotechnology company dedicated to improving immune health.

Contact:
David Walsh
VP Communications
Biothera, the Immune Health Company
651-256-4606 (direct)
651-675-0300 (main)
dwalsh@biothera.com

NASHVILLE, TENN — December 4, 2012 — Biothera provided samples of Wellmune WGP^®, a natural food and beverage ingredient clinically proven to strengthen the immune systems of athletes, at the Professional Baseball Strength & Conditioning Coaches Society (PBSCCS) 2012 Product Show & Symposium this past weekend.

Research shows that high intensity exercise temporarily weakens the immune system. Hard workouts can create an “open window” in the body’s defenses that may derail training programs and performance gains. Wellmune WGP boosts key immune cells that help keep the body healthy.

“Clinical research with marathoners, cyclists and others enduring high physical stress demonstrated how Wellmune WGP can strengthen immune defenses before and after exercise,” said Richard Mueller, Biothera chief executive officer. “We believe Wellmune would benefit pro baseball players whose long seasons and extensive travel constantly stress their bodies and immune systems.”

Wellmune supports immune health as evidenced by clinical research demonstrating reductions in upper respiratory tract infection (URTI) symptoms. In multiple clinical studies, Wellmune reduced the incidence of URTI symptoms that are common to athletes in many sports. In a double-blinded study involving 182 marathon runners last year, subjects taking Wellmune for four weeks experienced a 40% reduction in URTI symptoms.

About PBSCCS

The PBSCCS is a society of Strength and Conditioning Coaches composed from both Major League and Minor League baseball teams. It is committed to raising awareness about its role in professional baseball. Moreover, it is focused on the implementation of proven Strength and Conditioning principles & philosophies, community youth awareness programs, and long-term skills promoting performance and health. Through these programs, the PBSCCS will empower its coaches with the knowledge, skills, ethics, and competency to continue to increase the credibility and recognition of its coaches.

About Wellmune WGP^®

Wellmune WGP is a natural beta 1,3/1,6 glucan derived from a proprietary strain of yeast that is clinically proven to prime key immune cells that keep the body healthy. This unique food, beverage and supplement ingredient has regulatory approval around the world, including GRAS status in the U.S. and novel foods approval in Europe and China.  It is also patented, Kosher, Halal, non-allergenic and GMO-free. In addition to receiving an IFT Innovation Award, Wellmune has received a SupplySide West Scientific Excellence Award and a Frost & Sullivan Excellence in Research Award. Wellmune WGP is a product of Biothera, a U.S. biotechnology company dedicated to improving immune health.

Contact:
David Walsh
VP Communications
Biothera, the Immune Health Company
651-256-4606 (direct)
dwalsh@biothera.com

EAGAN, MN – October 22, 2012 – Wellmune WGP®, the clinically proven natural immune health ingredient from Biothera, is now available in a specially formulated beverage in Singapore called Take5ive Energy + Immunity Shot.

Take5ive Energy + Immunity Shot is a product of Avenza Pte Ltd. and works to increase energy and minimize the effects of stress, fatigue and tiredness that can weaken the immune system.

Energy shots are one of the growing categories of functional beverages and immune health is a sought-after benefit in functional foods and beverages. An estimated 57% of functional beverage buyers are seeking to “maintain a strong immune system,” Mintel International Group Ltd. noted in a recent research report.

Take5ive Energy + Immunity Shot is available in a choice of Mixed Berry and Citrus flavor. The 60-milliliter shot has no calories, sugar or carbs and includes 100% all-natural caffeine, Niacin, Folic Acid and vitamins B6 and B12. Designed for on-the-go convenience, the non-carbonated beverage does not require refrigeration.

“We specially formulated Take5ive Energy + Immunity for people who are stressed and over-worked to help them increase energy,” said Cathryn Chun, brand manager, Avenza Pte Ltd. “We were impressed by the breadth of research among high-stress populations using WelImune WGP. Wellmune time and again was found to help improve mental clarity, focus and concentration.”

“Consumers can enjoy this beverage shot with confidence in its ability to deliver real immune health benefits,” said Richard Mueller, president and CEO, Biothera. “In clinical research Wellmune protected firefighters, medical students and marathon runners from stress-related health challenges. Now consumers can ‘take five’ to take care of their immune health.”

Take5ive Energy + Immunity Shot joins a wide range of innovative food, beverage and supplement products with Wellmune WGP that are available in more than 50 countries around the world.

A half-bottle is the recommended serving size for normal energy and cognitive function; a full bottle provides maximum benefits.

About Wellmune WGP®
Wellmune WGP is a proprietary baker’s yeast beta 1,3/1,6 glucan that is clinically proven to prime key immune cells that keep the body healthy. This natural food, beverage and supplement ingredient has regulatory approval around the world, including GRAS status in the U.S. and novel foods approval in Europe and China. It is also patented, Kosher, Halal, non-allergenic and GMO-free. In addition to receiving an IFT Innovation Award, Wellmune has received a SupplySide West Scientific Excellence Award and a Frost & Sullivan Excellence in Research Award. Wellmune WGP is a product of Biothera, a U.S. biotechnology company dedicated to improving immune health.

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Contact:
David Walsh
VP Communications
Biothera, the Immune Health Company
651-256-4606 (direct)
651-675-0300 (main)
dwalsh@biothera.com

PHILADELPHIA – October 2, 2012 – Biothera, the maker of Wellmune WGP^®, an immune health ingredient for food, beverages and supplements, is bringing its immune health message to dietitians for the first time at the Academy of Nutrition and Dietetics’ Food and Nutrition Conference and Expo booth #1207 in Philadelphia Oct. 7-9.

Wellmune WGP^® is a natural ingredient clinically proven to safely prime the immune system to keep the body healthy. Numerous peer-reviewed studies demonstrate that Wellmune WGP mobilizes billions of innate immune cells that are part of the body’s natural defenses without stimulating the immune system.

Biothera will offer in-booth presentation about immune health and dietary interventions on Sunday, Oct. 7 from 11:45 a.m.-noon and 12:45-1:00 p.m.; and on Monday, Oct. 8 from noon-12:15 p.m. and from 1:00-1:15 p.m.

“There are exciting developments in the understanding of how better immune health can contribute to overall health and well being,” said Richard Mueller, chief executive officer, Biothera. “Ingredients like Wellmune WGP provide a safe and effective way to support the immune system for everyone in the family.

“Unlike other immune health ingredients, Wellmune is designed for everyday use year-round,” Mueller added. “As the body of clinical evidence reveals, Wellmune boosts immune cells that help keep the body healthy in times of stress and helps maintain healthy energy and mental clarity.”

Wellmune can be found in products ranging from juices, soups, bread, toddler formula, energy shots, dietary supplements, nutrition bars and smoothies. It is the culmination of $300 million in research and development. There are nine clinical studies demonstrating the effectiveness of Wellmune in reducing the symptoms of upper respiratory tract and lifestyle stress.

For more information about immune health topics for dietitians visit http://www.wellmune.com/for-dietitians/.

About Wellmune WGP^®

Wellmune WGP is a natural beta 1,3/1,6 glucan from a proprietary strain of baker’s yeast that is clinically proven to prime key immune cells that keep the body healthy. This unique food, beverage and supplement ingredient has regulatory approval around the world, including GRAS status in the U.S. and novel foods approval in Europe and China.  It is also patented, Kosher, Halal, non-allergenic and GMO-free. In addition to receiving an IFT Innovation Award, Wellmune has received a SupplySide West Scientific Excellence Award and a Frost & Sullivan Excellence in Research Award. Wellmune WGP is a product of Biothera, a U.S. biotechnology company dedicated to improving immune health.

Contact:
David Walsh
VP Communications
Biothera, the Immune Health Company
651-256-4606 (direct)
651-675-0300 (main)
dwalsh@biothera.com

EAGAN, MN — October 1, 2012 — Biothera has named Ryusendo Co., Ltd. as its exclusive distributor in Japan of Wellmune WGP^® and the company’s ot her immune health ingredients for foods, beverages, and supplements

Wellmune WGP is a natural ingredient that is clinically proven to enhance key immune cells that help keep the body healthy.  This natural beta 1,3/1,6 glucan from a proprietary strain of baker’s yeast is an ingredient in foods, beverage and supplements in more than 50 countries.  Numerous peer-reviewed clinical studies provide strong support for the safety and efficacy of Wellmune WGP, which is widely recognized as the leading immune health ingredient.

“Ryusendo is well established in the Japanese marketplace with strong customer relationships and highly trained sales force that excels at representing science-based specialty ingredients,” said Richard Mueller, chief executive officer of Biothera.  “Ryusendo is a great fit for Biothera and for Wellmune WGP.”

“Immune support is rapidly growing category spanning a broad range of consumers — from infants to the elderly — and we are excited to make the immune health benefits of Wellmune available to the Japanese people,” ” said Yoshiaki Shiojima, CEO of Ryusendo Co., Ltd.  “Wellmune is an excellent addition to our portfolio that provides new opportunities for formulating in beverages and conventional foods as well as health foods.”

About Ryusendo Co., Ltd.

Ryusendo Co., Ltd. researches and develops innovative health food products with an emphasis on safety and strong scientific evidence.  In addition to manufacturing and marketing supplements, the company is a leading importer and exporter of raw materials for health foods. Based in Tokyo, Ryusendo recently moved to new offices to accommodate increasing the number of customer visits and seminars as well as the number of employees.  Ryusendo is engaged in joint research projects with various universities and institutes and participates in numerous exhibitions. On October 3-5, Ryusendo will feature Wellmune WGP at HI Japan 2012 at the Tokyo Exhibition Center.

About Wellmune WGP^®

Wellmune WGP is a natural beta 1,3/1,6 glucan derived from a proprietary strain of yeast that is clinically proven to prime key immune cells that keep the body healthy. This unique food, beverage and supplement ingredient has regulatory approval around the world, including GRAS status in the U.S. and novel foods approval in Europe and China.  It is also patented, Kosher, Halal, non-allergenic and GMO-free. In addition to receiving an IFT Innovation Award, Wellmune has received a SupplySide West Scientific Excellence Award and a Frost & Sullivan Excellence in Research Award. Wellmune WGP is a product of Biothera, a U.S. biotechnology company dedicated to improving immune health.

Contact:
David Walsh
VP Communications
Biothera, the Immune Health Company
651-256-4606 (direct)
dwalsh@biothera.com

EAGAN, Minn., September 19, 2012 – Wellmune WGP^®, the immune health ingredient from Biothera, is now available for the first time in a beverage product in the European Union. This latest innovation in functional beverages with Wellmune WGP follows the 2011 European Food Safety Authority (EFSA) Panel on Dietetic Products, Nutrition and Allergies positive scientific opinion on Wellmune WGP® as a novel food.

A new line of Alibi Pretox functional beverages from Solution Sciences Ltd. of London, will include Wellmune for immune support, along with Vitamin K for bone and heart health. The Alibi Pretox beverages are sparkling health drinks that support a proactive approach to daily health by preparing and protecting the body with enhanced levels of nutrition.

“Wellmune’s everyday immune support benefits align well with Alibi’s focus on supporting the body’s natural ability to stay well,” said Richard Mueller, CEO, Biothera. “This product is a great example of innovation in the functional beverage category using ingredients backed by sound science.”

Wellmune WGP is clinically proven to safely prime the immune system to keep the body healthy. Numerous peer-reviewed studies demonstrate that Wellmune WGP mobilizes billions of innate immune cells that are part of the body’s natural defenses without over stimulating the immune system.

Wellmune WGP is the only yeast-derived beta glucan to receive the novel food designation and be permitted for use in foods, beverages and supplements in Europe.

About Wellmune WGP^®

Wellmune WGP is a natural beta 1,3/1,6 gluco polysaccharide that is clinically proven to prime key immune cells that keep the body healthy. This unique food, beverage and supplement ingredient has regulatory approval around the world, including GRAS status in the U.S. and novel foods approval in Europe and China.  It is also patented, Kosher, Halal, non-allergenic and GMO-free. In addition to receiving an IFT Innovation Award, Wellmune has received a SupplySide West Scientific Excellence Award and a Frost & Sullivan Excellence in Research Award. Wellmune WGP is a product of Biothera, a U.S. biotechnology company dedicated to improving immune health.

 Contact:
David Walsh
VP Communications
Biothera, the Immune Health Company
651-256-4606 (direct)
651-675-0300 (main)
dwalsh@biothera.com

EAGAN, Minn., August 9, 2012 – Wellmune WGP^®, the immune health ingredient from Biothera, continues to expand its availability in Thailand with the addition of a new dietary supplement distributed by Aim Star Network, a leading multi-level marketing company focused on dietary supplements, cosmetics and personal care products. Multi Pro is a protein-based dietary supplement suitable for all ages.

Wellmune WGP is clinically proven to safely prime the immune system to keep the body healthy.  Numerous peer-reviewed studies demonstrate that Wellmune WGP mobilizes billions of innate immune cells that are part of the body’s natural defenses without over stimulating the immune system.

“We’re always looking to bring innovative ingredients that could deliver high value to our consumers,” said Labha Watcharasriroj, founder, Aim Star Network, noting that there are more than 1 million representatives and members of the Aim Star Network. “The science behind Wellmune WGP will get everyone talking.”

“Multi Pro offers the convenience of daily immune support to promote overall health and well being,” said Rich Mueller, president and CEO, Biothera. “Aim Star Business Owners can recommend Multi Pro with confidence, knowing that they are offering a product with clinically proven immune health benefits.”

In addition to containing Wellmune WGP, the combination powder dietary supplement has whey protein isolate, isolated soy protein, milk protein hydrolysate, branch chain amino acid, fish hydrolyzed collagen and creatine monohydrate.

About Wellmune WGP^®

Wellmune WGP is a natural beta 1,3/1,6 gluco polysaccharide that is clinically proven to prime key immune cells that keep the body healthy. This unique food, beverage and supplement ingredient has regulatory approval around the world, including GRAS status in the U.S. and novel foods approval in Europe and China.  It is also patented, Kosher, Halal, non-allergenic and GMO-free. In addition to receiving an IFT Innovation Award, Wellmune has received a SupplySide West Scientific Excellence Award and a Frost & Sullivan Excellence in Research Award. Wellmune WGP is a product of Biothera, a U.S. biotechnology company dedicated to improving immune health.

Contact:
David Walsh
VP Communications
Biothera, the Immune Health Company
651-256-4606 (direct)
651-675-0300(main)
dwalsh@biothera.com

Data presented at International Carbohydrate Symposium

EAGAN, MN — August 2, 2012 — Biothera researchers enhanced the biological activity of a fungal beta glucan by altering its molecular structure, confirming previous research demonstrating the link between branching and functionality, according to data presented last week at the International Carbohydrate Symposium in Madrid.

For the study, carbohydrate chemists at Biothera used scleroglucan, a fungal beta 1,3 glucan that is highly branched with single glucose molecules.  When the branching was reduced from 30% to 12%, the average molecular weight increased, indicating the formation of complex higher ordered structures.  The single helical structures aggregated into triple helical structures that significantly increased their biological activity.

“By changing the molecular structure, we were able to transform a relatively inactive fungal beta glucan into one with greater biological activity,” said Dan Conners, president of Biothera’s Pharmaceutical Group. “This research highlights Biothera’s expertise in carbohydrate chemistry and our unmatched knowledge of beta glucan biotechnology.”

“The data confirms our earlier studies demonstrating that structure matters and that not all beta glucans are created equal,” said Rich Mueller, president of Biothera’s Healthcare Group.  “Ingredient or product claims must be supported by research with that specific ingredient and strain and not borrowed research.”

The poster presented at the symposium was entitled, “Modification of a Beta Glucan Affects Aggregation Behavior and Biological Activity.”  Authors: Magee, A.S.; Langeslay, R.R.; Will, P.M.; Elmasry, N.A.; Danielson, M.E.  Abstract.

Previous Biothera research showing that subtle differences in the molecular structure of various beta 1,3/1,6 glucans can significantly affect their ability to enhance innate immune system responses was presented at the National Cancer Institute.

About Biothera, the immune health company

Biothera is a biotechnology company dedicated to improving immune health. The company is commercializing its unique technology platform through two business groups. Biothera’s Pharmaceutical Group is conducting multiple clinical trials for the development of a drug that mobilizes the innate immune system to fight most types of cancer. The company’s Healthcare Group is a leading provider of natural immune health ingredients for functional foods, beverages, dietary supplements, cosmetics and animal nutrition.

Contact:
David Walsh
VP Communications
Biothera, the Immune Health Company
651-256-4606 (direct)
dwalsh@biothera.com